There seems to be an issue with Trend Micro and Windows Defender after Windows/ Defender patches has been applied.

The quick workaround is to deploy are registry key:
HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows Defender
The dword value should be 1: DisableAntiSpyware

In case it does not exist, go ahead and create it.
Restart and you should see things start working again.

If you have the issue, you should be able to deploy it using Group Policy Preferences.

NOTE: You can also enter safe mode and create the needed key.

Reference links:

https://technet.microsoft.com/en-us/library/cc749126(v=ws.10).aspx

https://docs.microsoft.com/en-us/windows/threat-protection/windows-defender-antivirus/deploy-manage-report-windows-defender-antivirus

https://support.microsoft.com/en-us/help/12376/windows-10-start-your-pc-in-safe-mode